Synapse Research Institute was founded in 1999 as a research institute to explore thrombin generation (TG). Synapse is the inventor and patent holder of the “calibrated TG”, which is the world standard for thrombin generation measurements.

Calibrated TG measures both thrombotic and bleeding tendencies. There is increasing awareness amongst scientists and medical doctors that the calibrated TG is the most physiological test, to measure the coagulation state of patients, in vitro.



Calibrated TG is the solution for the prediction of (venous) thrombosis risk in patients with atrial fibrillation, cancer, APC-resistance and inflammatory disorders. Furthermore, calibrated TG gives the most complete view of coagulation in patients with high bleeding risk.

The aim of Synapse Research Institute is to be the centre of haemostasis research. Therefore, we do top quality research, invest in innovation of coagulation measurements and follow the highest quality standards to support clinical studies.

The infrastructure of Synapse Research Institute consists of three types of laboratories:

  1. Research laboratories, which are equipped with the newest innovations in thrombosis and haemostasis research
  2. A service laboratory which is organized according to the “Good Laboratory Practice” (GLP) standards
  3. A purification laboratory, which is equipped for large scale purification of plasma proteins.

Synapse is acting in the niche between biochemical, pharmaceutical- and clinical sciences.
Since 2009 Synapse is member of STAGO.